LESM: a laser-driven sub-MeV electron source delivering ultra-high dose rate on thin biological samples

Year: 2016

Authors: Labate L., Andreassi MG., Baffigi F., Bizzarri R., Borghini A., Bussolino GC., Fulgentini L., Ghetti F., Giulietti A., Koster P., Lamia D., Levato T., Oishi Y., Pulignani S., Russo G., Sgarbossa A., Gizzi LA.

Autors Affiliation: CNR, Ist Nazl Ott, Pisa, Italy; CNR, Ist Fisiol Clin, Pisa, Italy; CNR, Ist Nanosci, NEST, Pisa, Italy; Scuola Normale Super Pisa, Pisa, Italy; CNR, LATO, Ist Bioimmagini & Fisiol Mol, Cefalu, Italy; Acad Sci Czech Republic, Inst Phys, ELI Beamlines, Prague, Czech Republic; Cent Res Inst Elect Power Ind, Yokosuka, Kanagawa, Japan; Ist Nazl Fis Nucl, Sez Pisa, Pisa, Italy.

Abstract: We present a laser-driven source of electron bunches with average energy 260 keV and picosecond duration, which has been setup for radiobiological tests covering the previously untested sub-MeV energy range. Each bunch combines high charge with short duration and sub-millimeter range into a record instantaneous dose rate, as high as 10(9) Gy s(-1). The source can be operated at 10 Hz and its average dose rate is 35 mGy s(-1). Both the high instantaneous dose rate and high level of relative biological effectiveness, attached to sub-MeV electrons, make this source very attractive for studies of ultrafast radiobiology on thin cell samples. The source reliability, in terms of shot-to-shot stability of features such as mean energy, bunch charge and transverse beam profile, is discussed, along with a dosimetric characterization. Finally, a few preliminary biological tests performed with this source are presented.

Journal/Review: JOURNAL OF PHYSICS D-APPLIED PHYSICS

Volume: 49 (27)      Pages from: 275401-1  to: 275401-9

More Information: The activity of the INO-CNR Pisa group was partially supported from the Italian Ministry of Health through the Project No. GR-2009-1608935 (Study of Radiobiological and Radiotherapic Effects of a Novel Laser-Driven Electron Accelerator, D.I. AgeNaS), from the CNR funded Italian research Network ELI-Italy (Attoseconds) and from the PRIN project (Contract No. PRIN2012AY5LEL). The Pisa authors also acknowledge contribution from the MIUR-FIRB project SPARX (Sorgente Pulsata Auto-Amplificata di Radiazione X) and the INFN gResist and Plasma-med collaborations.
KeyWords: Sub-MeV electron sources; Laser-driven electron accelerators; Ultrahigh dose rate; Cell radiation; Radiobioplogy
DOI: 10.1088/0022-3727/49/27/275401

ImpactFactor: 2.588
Citations: 10
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