High statistics block entropy measures of DNA sequences
Year: 1996
Authors: Lio P., Politi A., Buiatti M., Ruffo S.
Autors Affiliation: Dipartimento di Biologia Animale e Genetica, Università di Firenze, Via Romana 17, 50125 Firenze, Italy; Istituto Nazionale di Ottica, Largo E. Fermi 6, 50125 Firenze, Italy; Dipartimento di Energetica, Università di Firenze, Via S. Marta 3, 50139 Firenze, Italy; INFN, Sez. di Firenze Italy
Abstract: We have used an improved block-entropy measure in order to gain some further insights into the short-range correlations present in whole chromosomes of S. cerevisiae, viruses and organelles and very large genomic regions of E. coli. Although DNA sequences are largely inhomogeneous and word frequencies are unevenly distributed, the comparison of entire chromosomes and large genomic regions show a ’’bulk’’ composition homogeneity. This property suggests that biases in selection, directional mutational pressure and recombination processes act in homogenizing the base composition of the DNA molecules within a genome but their mode of action, relative impact and direction may vary in different organisms. The most interesting results appear to be the differences between the SW (C,G/A,T) and RY (A,G/C,T) two-letter alphabet entropies. Deviations from randomness in E. coli and S. cerevisiae sequences particularly concern SW dinucleotide frequencies and RY tetranucleotide frequencies.
Journal/Review: JOURNAL OF THEORETICAL BIOLOGY
Volume: 180 (2) Pages from: 151 to: 160
KeyWords: Nucleotide-sequences; Codon Usage; Genome; Mutation; Recombination; Constraints; Stability; Evolution; RnaDOI: 10.1006/jtbi.1996.0091Citations: 29data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2024-11-10References taken from IsiWeb of Knowledge: (subscribers only)Connecting to view paper tab on IsiWeb: Click hereConnecting to view citations from IsiWeb: Click here
