A molecular imaging analysis of Cx43 association with Cdo during skeletal myoblast differentiation
Year: 2013
Authors: Nosi D., Mercatelli R., Chellini F., Soria S., Pini A., Formigli L., Quercioli F.
Autors Affiliation: Dipartimento di Anatomia, Istologia e Medicina Legale, Universita` di Firenze, Largo Brambilla 3 – Firenze, Italy;
Istituto dei Sistemi Complessi, Consiglio Nazionale delle Ricerche, via Madonna del Piano 10 – Sesto Fiorentino, Italy;
Istituto di Fisica Applicata Nello Carrara, Consiglio Nazionale delle Ricerche, via Madonna del Piano 10 – Sesto Fiorentino, Italy;
Istituto Nazionale di Ottica, Consiglio Nazionale delle Ricerche, Via Nello Carrara 1 – Sesto Fiorentino, Italy
Abstract: Cell-to-cell contacts are crucial for cell differentiation. The promyogenic cell surface protein, Cdo, functions as a component of multiprotein clusters to mediate cell adhesion signaling. Connexin 43, the main connexin forming gap junctions, also plays a key role in myogenesis. At least part of its effects is independent of the intercellular channel function, but the mechanisms underlying are unknown. Here, using multiple optical approaches, we provided the first evidence that Cx43 physically interacts with Cdo to form dynamic complexes during myoblast differentiation, offering clues for considering this interaction a structural basis of the channel-independent function of Cx43.
Journal/Review: JOURNAL OF BIOPHOTONICS
Volume: 6 (8) Pages from: 612 to: 621
More Information: F. Quercioli wishes to thank Ente Cassa di Risparmio di Firenze for the granted funding.DOI: 10.1002/jbio.201200063ImpactFactor: 3.856Citations: 14data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2024-11-24References taken from IsiWeb of Knowledge: (subscribers only)Connecting to view paper tab on IsiWeb: Click hereConnecting to view citations from IsiWeb: Click here
