Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases
Year: 2010
Authors: Cardona F., Goti A., Parmeggiani C., Parenti P., Forcella M., Fusi P., Cipolla L., Roberts S.M., Davies G.J., Gloster T.M.
Autors Affiliation: Department of Chemistry “U. Schiff”, Laboratory of Design, Synthesis and Study of Biologically Active Heterocycles (HeteroBioLab), University of Florence, Via della Lastruccia 3-13, 50019, Sesto Fiorentino, Florence, Italy; Department of Environmental Sciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milano, Italy; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy; Structural Biology Laboratory, Department of Chemistry, The University of York, Heslington, York, YO10 5YW, U.K.
Abstract: Two novel casuarine-6-alpha-D-glucoside analogues, as well as the parent compound, were synthesized and tested as inhibitors towards Chironomus riparius, mammalian pig kidney and Escherichia coli trehalases. Their potent and selective activity is promising for the development of new insecticides.
Journal/Review: CHEMICAL COMMUNICATIONS
Volume: 46 (15) Pages from: 2629 to: 2632
More Information: We thank Prof. S. G. Withers, University of British Columbia, Canada and Prof. D. R. Rose, Department of Biology, University of Waterloo, Canada, for inhibition tests towards HPA and NtMGAM. We thank MiUR (PRIN 2008) and Ente Cassa di Risparmio di Firenze, Italy, for financial support. T. M. G. is a Sir Henry Wellcome postdoctoral fellow and G.J.D. holds a Royal Society Wolfson Research Merit Award. The work was supported in part by a grant from the University of Milano-Bicocca (FA 2008).DOI: 10.1039/b926600cImpactFactor: 5.787Citations: 38data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2024-11-10References taken from IsiWeb of Knowledge: (subscribers only)Connecting to view paper tab on IsiWeb: Click hereConnecting to view citations from IsiWeb: Click here
