Quantum photonics sensing in biosystems
Year: 2025
Authors: Moreva E., Cimini V., Gianani I., Bernardi E., Traina P., Degiovanni I.P., Barbieri M.
Autors Affiliation: Ist Nazl Ric Metrol, Str Cacce 91, I-10135 Turin, Italy; Sapienza Univ Roma, Dipartimento Fis, Ple A Moro 5, I-00185 Rome, Italy; Univ Roma Tre, Dip Sci, Via Vasca Navale 84, I-00146 Rome, Italy; CNR, Ist Nazl Ott, Largo E Fermi 6, I-50125 Florence, Italy.
Abstract: Quantum sensors emerged among quantum technologies as the ones with promising potential applications in the near future. This perspective reviews two leading quantum sensing platforms and their advancements toward biological applications: quantum light sources and color centers in diamonds. Quantum light, including squeezed states and N00N states, allows enhanced phase measurements by surpassing the classical shot noise limits. This advantage can be exploited in several contexts, enabling improved resolution and sensitivity, which are particularly valuable in biological contexts where traditional high-intensity illumination could damage or alter delicate samples. In parallel, color centers in diamonds, specifically nitrogen-vacancy and silicon-vacancy centers, also emerged as promising for sensing applications due to their high sensitivity and biocompatibility. These sensors enable detailed intracellular measurements, such as temperature detection, and show potential for measuring magnetic fields of biological origin. Despite these advancements, significant challenges remain in translating these technologies from a controlled laboratory environment to practical, widely applicable devices for diverse biological applications. Overcoming these challenges is crucial for unlocking the full potential of quantum sensors in the biological field.
Journal/Review: APL PHOTONICS
Volume: 10 (1) Pages from: 10902-1 to: 10902-13
More Information: We thank Fabio Sciarrino for stimulating the discussion. This work was financially supported by the Qu-Test project, which has received the funding from the European Union’s Horizon Europe Research and Innovation Program under Grant Agreement No. 101113901; by Project No. 23NRM04 NoQTeS, funded by the European Partnership on Metrology, co-financed from the European Union’s Horizon Europe Research and Innovation Program and by the participating states; and by the European Commission FET-OPEN-RIA project STORMYTUNE, Grant Agreement No. 899587. I.G. and M.B. are supported by MUR Dipartimento di Eccellenza 2023-2027. V.C. is supported by the PNRR MUR Project No. PE0000023-NQSTI (Spoke 4).KeyWords: Optical Coherence Tomography; Laser Irradiation; Squeezed-light; Single-neuron; Microscopy; Noise; Nm; Nanodiamonds; Thermometers; CellsDOI: 10.1063/5.0232183
