ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research
Year: 2021
Authors: Odening KE., Gomez AM., Dobrev D., Fabritz L., Heinzel FR., Mangoni ME., Molina CE., Sacconi L., Smith G., Stengl M., Thomas D., Zaza A., Remme CA., Heijman J.
Autors Affiliation: Bern Univ Hosp, Dept Cardiol, Inselspital, Translat Cardiol, Bern, Switzerland; Univ Bern, Inst Physiol, Bern, Switzerland; Univ Paris Saclay, INSERM, Signaling & Cardiovasc Pathophysiol, UMR S 1180, F-92296 Chatenay Malabry, France; Univ Duisburg Essen, West German Heart & Vasc Ctr, Inst Pharmacol, Essen, Germany; Univ Birmingham, Inst Cardiovasc Sci, Birmingham, W Midlands, England; Univ Hosp Birmingham NHS Trust, Dept Cardiol, Birmingham, W Midlands, England; Charite Univ Med Berlin, Dept Internal Med & Cardiol, Campus Virchow Klinikum, Berlin, Germany; DZHK German Ctr Cardiovasc Res, Partner Site, Berlin, Germany; Univ Montpellier, Inst Genom Fonct, INSERM, CNRS, Montpellier, France; Univ Med Ctr Hamburg Eppendorf, Inst Expt Cardiovasc Res, Hamburg, Germany; German Ctr Cardiovasc Res DZHK, Partner Site, Hamburg, Germany; Natl Inst Opt, Sesto Fiorentino, Italy; European Lab Non Linear Spect, Sesto Fiorentino, Italy; Univ Freiburg, Inst Expt Cardiovasc Med, Freiburg, Germany; Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland; Charles Univ Prague, Fac Med Pilsen, Dept Physiol, Plzen, Czech Republic; Univ Hosp Heidelberg, Dept Cardiol, Heidelberg, Germany; German Ctr Cardiovasc Res DZHK, Partner Site, Heidelberg, German y; Univ Milano Bicocca, Dept Biotechnol & Biosci, Milan, Italy; Amsterdam UMC, Locat AMC, Dept Expt Cardiol, Amsterdam, Netherlands; Maastricht Univ, CARIM Sch Cardiovasc Dis, Dept Cardiol, Maastricht, Netherlands.
Abstract: Cardiac arrhythmias are a major cause of death and disability. A large number of experimental cell and animal models have been developed to study arrhythmogenic diseases. These models have provided important insights into the underlying arrhythmia mechanisms and translational options for their therapeutic management. This position paper from the ESC Working Group on Cardiac Cellular Electrophysiology provides an overview of (i) currently available in vitro, ex vivo, and in vivo electrophysiological research methodologies, (ii) the most commonly used experimental (cellular and animal) models for cardiac arrhythmias including relevant species differences, (iii) the use of human cardiac tissue, induced pluripotent stem cell (hiPSC)-derived and in silico models to study cardiac arrhythmias, and (iv) the availability, relevance, limitations, and opportunities of these cellular and animal models to recapitulate specific acquired and inherited arrhythmogenic diseases, including atrial fibrillation, heart failure, cardiomyopathy, myocarditis, sinus node, and conduction disorders and channelopathies. By promoting a better understanding of these models and their limitations, this position paper aims to improve the quality of basic research in cardiac electrophysiology, with the ultimate goal to facilitate the clinical translation and application of basic electrophysiological research findings on arrhythmia mechanisms and therapies.
Journal/Review: EUROPACE
Volume: 23 (11) Pages from: 1795 to: 1814
KeyWords: Animal models; Experimental models; Arrhythmias; Atrial fibrillation; Mechanisms; Cardiac electrophysiology; Cellular electrophysiology; Ion channels; Position paperDOI: 10.1093/europace/euab142ImpactFactor: 5.486Citations: 26data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2024-11-24References taken from IsiWeb of Knowledge: (subscribers only)Connecting to view paper tab on IsiWeb: Click hereConnecting to view citations from IsiWeb: Click here
