Distributed and Localized Dynamics Emerge in the Mouse Neocortex during Reach-to-Grasp Behavior
Year: 2022
Authors: Quarta Eros; Scaglione Alessandro; Lucchesi Jessica; Sacconi Leonardo; Mascaro Anna Letizia Allegra; Pavone Francesco Saverio
Autors Affiliation: Univ Florence, Dept Phys & Astron, I-50019 Florence, Italy; European Lab Nonlinear Spect, I-50019 Florence, Italy; CNR, Natl Inst Opt, I-50019 Florence, Italy; CNR, Neurosci Inst, I-56124 Pisa, Italy.
Abstract: A long-standing question in systems neuroscience is to what extent task-relevant features of neocortical processing are localized or distributed. Coordinated activity across the neocortex has been recently shown to drive complex behavior in the mouse, while activity in selected areas is canonically associated with specific functions (e.g., movements in the case of the motor cortex). Reach-to-grasp (RtG) movements are known to be dependent on motor circuits of the neocortex; however, the global activity of the neocortex during these movements has been largely unexplored in the mouse. Here, we characterized, using wide-field calcium imaging, these neocortex-wide dynamics in mice of either sex engaging in an RtG task. We demonstrate that, beyond motor regions, several areas, such as the visual and the retrosplenial cortices, also increase their activity levels during successful RtGs, and homologous regions across the ipsilateral hemisphere are also involved. Functional connectivity among neocortical areas increases transiently around movement onset and decreases during movement. Despite this global phenomenon, neural activity levels correlate with kinematics measures of successful RtGs in sensorimotor areas only. Our findings establish that distributed and localized neocortical dynamics co-orchestrate efficient control of complex movements.
Journal/Review: JOURNAL OF NEUROSCIENCE
Volume: 42 (5) Pages from: 777 to: 788
KeyWords: calcium imaging; functional connectivity; neocortex; neural dynamics; reach-to-grasp; voluntary movementDOI: 10.1523/JNEUROSCI.0762-20.2021ImpactFactor: 5.300Citations: 11data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2024-11-24References taken from IsiWeb of Knowledge: (subscribers only)Connecting to view paper tab on IsiWeb: Click hereConnecting to view citations from IsiWeb: Click here