BackAuthor: Costantini Irene 1) Universal autofocus for quantitative volumetric microscopy of whole mouse brains in NATURE METHODSBy: Silvestri L., Mullenbroich MC., Costantini I., Di Giovanna AP., Mazzamuto G., Franceschini A., Kutra D., Kreshuk A., Checcucci C., Toresano LO., Frasconi P., Sacconi L., Pavone FS. Year: 2021 (IF.: 47.990 Cit.: 31 DOI: 10.1038/s41592-021-01208-1)
2) Toward a High-Resolution Reconstruction of 3D Nerve Fiber Architectures and Crossings in the Brain Using Light Scattering Measurements and Finite-Difference Time-Domain Simulations in PHYSICAL REVIEW XBy: Menzel M., Axer M., De Raedt H., Costantini I., Silvestri L., Pavone FS., Amunts K., Michielsen K. Year: 2020 (IF.: 15.762 Cit.: 17 DOI: 10.1103/PhysRevX.10.021002)
3) A cellular resolution atlas of Broca’s area in SCIENCE ADVANCESBy: Costantini I., Morgan L., Yang JR., Balbastre Y., Varadarajan D., Pesce L., Scardigli M., Mazzamuto G., Gavryusev V., Castelli FM., Roffilli M., Silvestri L., Laffey J., Raia S., Varghese M., Wicinski B., Chang SB., Chen IA., Wang H., Cordero D., Vera M., Nolan J., Nestor K., Mora J., Iglesias JE., Pallares EG., Evancic K., Augustinack JC., Fogarty M., Dalca AV., Frosch MP., Magnain C., Frost R., van der Kouwe A., Chen SC., Boas DA., Pavone FS., Fischl B., Hof PR. Year: 2023 (IF.: 11.700 Cit.: 8 DOI: 10.1126/sciadv.adg3844)
4) Brain-wide neuron quantification toolkit reveals strong sexual dimorphism in the evolution of fear memory in CELL REPORTSBy: Franceschini A., Mazzamuto G., Checcucci C., Chicchi L., Fanelli D., Costantini I., Passani MB., Silva BA., Pavone FS., Silvestri L. Year: 2023 (IF.: 7.500 Cit.: 2 DOI: 10.1016/j.celrep.2023.112908)
5) 3D molecular phenotyping of cleared human brain tissues with light-sheet fluorescence microscopy in COMMUNICATIONS BIOLOGYBy: Pesce Luca; Scardigli Marina; Gavryusev Vladislav; Laurino Annunziatina; Mazzamuto Giacomo; Brady Niamh; Sancataldo Giuseppe; Silvestri Ludovico; Destrieux Christophe; Hof Patrick R.; Costantini Irene; Pavone Francesco S. Year: 2022 (IF.: 5.900 Cit.: 22 DOI: 10.1038/s42003-022-03390-0)
6) Neurophotonic tools for microscopic measurements and manipulation: status report in NEUROPHOTONICSBy: Abdelfattah AS., Ahuja S., Akkin T., Allu SR., Brake J., Boas DA., Buckley EM., Campbell RE., Chen AI., Cheng XJ., Cizmbr T., Costantini I., De Vittorio M., Devor A., Doran PR., El Khatib M., Emiliani V., Fomin-Thunemann N., Fainman Y., Fernandez-Alfonso T., Ferri CGL., Gilad A., Han X., Harris A., Hillman EMC., Hochgeschwender U., Holt MG., Ji N., Kiliz K., Lake EMR., Li L., Li TQ., Mdchler P., Miller EW., Mesquita RC., Nadella KMNS., Ndgerl UV., Nasu Y., Nimmerjahn A., Ondrbckovb P., Pavone FS., Campos CP., Peterka DS., Pisano F., Pisanello F., Puppo F., Sabatini BL., Sadegh S., Sakadzic S., Shoham S., Shroff SN., Silver RA., Sims RR., Smith SL., Srinivasan VJ., Thunemann M., Tian L., Tian L., Troxler T., Valera A., Vaziri A., Vinogradov SA., Vitale F., Wang LV., Uhlnrovb H., Xu C., Yang CHE., Yang MH., Yellen G., Yizhar O., Zhao YX. Year: 2022 (IF.: 5.300 Cit.: 29 DOI: 10.1117/1.NPh.9.S1.013001)
7) A promoter polymorphism in human interleukin-32 modulates its expression and influences the risk and the outcome of epithelial cell-derived thyroid carcinoma in CARCINOGENESISBy: Plantinga T.S., Costantini I., Heinhuis B., Huijbers A., Semango G., Kusters B., Netea M.G., Hermus A.R.M.M., Smit J.W.A., Dinarello C.A., Joosten L.A.B., Netea-Maier R.T. Year: 2013 (IF.: 5.266 Cit.: 33 DOI: 10.1093/carcin/bgt092)
8) A versatile clearing agent for multi-modal brain imaging in SCIENTIFIC REPORTSBy: Costantini I., Ghobril J.P., Di Giovanna A.P., Allegra Mascaro A. L., Silvestri L., Müllenbroich M.C., Onofri L., Conti V., Vanzi F., Sacconi L., Guerrini R., Markram H., Iannello G., Pavone F.S. Year: 2015 (IF.: 5.228 Cit.: 192 DOI: 10.1038/srep09808)
9) Autofluorescence enhancement for label‑free imaging of myelinated fibers in mammalian brains in SCIENTIFIC REPORTSBy: Costantini I., Baria E., Sorelli M., Matuschke F., Giardini F., Menzel M., Mazzamuto G., Silvestri L., Cicchi R., Amunts K., Axer M., Pavone F.S. Year: 2021 (IF.: 4.996 Cit.: 19 DOI: 10.1038/s41598-021-86092-7)
10) A Guide to Perform 3D Histology of Biological Tissues with Fluorescence Microscopy in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESBy: Laurino A., Franceschini A., Pesce L., Cinci L., Montalbano A., Mazzamuto G., Sancataldo G., Nesi G., Costantini I., Silvestri L., Pavone FS. Year: 2023 (IF.: 4.900 Cit.: 7 DOI: 10.3390/ijms24076747)
11) Exploring the human cerebral cortex using confocal microscopy in PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGYBy: Pesce Luca; Laurino Annunziatina; Scardigli Marina; Yang Jiarui; Boas David A.; Hof Patrick R.; Destrieux Christophe; Costantini Irene; Pavone Francesco Saverio Year: 2021 (IF.: 4.799 Cit.: 12 DOI: 10.1016/j.pbiomolbio.2021.09.001)
12) Quantification of Myocyte Disarray in Human Cardiac Tissue in FRONTIERS IN PHYSIOLOGYBy: Giardini F., Lazzeri E., Vitale G., Ferrantini C., Costantini I., Pavone FS., Poggesi C., Bocchi L., Sacconi L. Year: 2021 (IF.: 4.755 Cit.: 5 DOI: 10.3389/fphys.2021.750364)
13) Dissecting Neuronal Activation on a Brain-Wide Scale With Immediate Early Genes in FRONTIERS IN NEUROSCIENCEBy: Franceschini A., Costantini I., Pavone FS., Silvestri L. Year: 2020 (IF.: 4.677 Cit.: 27 DOI: 10.3389/fnins.2020.569517)
14) Automated computation of nerve fibre inclinations from 3D polarised light imaging measurements of brain tissue in SCIENTIFIC REPORTSBy: Menzel M., Reuter JA., Graessel D., Costantini I., Amunts K., Axer M. Year: 2022 (IF.: 4.600 Cit.: 4 DOI: 10.1038/s41598-022-08140-0)
15) Cardiac sympathetic innervation network shapes the myocardium by locally controlling cardiomyocyte size through the cellular proteolytic machinery in JOURNAL OF PHYSIOLOGY-LONDONBy: Pianca N., Di Bona A., Lazzeri E., Costantini I., Franzoso M., Prando V., Armani A., Rizzo S., Fedrigo M., Angelini A., Basso C., Pavone FS., Rubart M., Sacconi L., Zaglia T., Mongillo M. Year: 2019 (IF.: 4.547 Cit.: 37 DOI: 10.1113/JP276200)
16) 3D imaging and morphometry of the heart capillary system in spontaneously hypertensive rats and normotensive controls in SCIENTIFIC REPORTSBy: Olianti C., Costantini I., Giardini F., Lazzeri E., Crocini C., Ferrantini C., Pavone FS., Camici PG., Sacconi L. Year: 2020 (IF.: 4.379 Cit.: 18 DOI: 10.1038/s41598-020-71174-9)
17) Whole-Brain Vasculature Reconstruction at the Single Capillary Level in SCIENTIFIC REPORTSBy: Di Giovanna A.P., Tibo A., Silvestri L., Muellenbroich M.C., Costantini I., Allegra Mascaro A.L., Sacconi L., Frasconi P., Pavone F.S. Year: 2018 (IF.: 4.011 Cit.: 86 DOI: 10.1038/s41598-018-30533-3)
18) Publisher Correction: Whole-Brain Vasculature Reconstruction at the Single Capillary Level (Scientific Reports, (2018), 8, 1, (12573), 10.1038/s41598-018-30533-3) in SCIENTIFIC REPORTSBy: Di Giovanna A.P., Tibo A., Silvestri L., Mullenbroich M.C., Costantini I., Allegra Mascaro A.L., Sacconi L., Frasconi P., Pavone F.S. Year: 2019 (IF.: 3.998 DOI: 10.1038/s41598-019-42216-8)
19) Gene polymorphisms in pattern recognition receptors and susceptibility to idiopathic recurrent vulvovaginal candidiasis in FRONTIERS IN MICROBIOLOGYBy: Rosentul D.C., Delsing C.E., Jaeger M., Plantinga T.S., Oosting M., Costantini I., Venselaar H., Joosten L.A.B., van der Meer J.W.M., Dupont B., Kullberg B.-J., Sobel J.D., Netea M.G. Year: 2014 (IF.: 3.989 Cit.: 48 DOI: 10.3389/fmicb.2014.00483)
20) In-vivo and ex-vivo optical clearing methods for biological tissues: review in BIOMEDICAL OPTICS EXPRESSBy: Costantini I., Cicchi R., Silvestri L., Vanzi F., Pavone F.S. Year: 2019 (IF.: 3.921 Cit.: 116 DOI: 10.1364/BOE.10.005251)
21) Optical clearing in cardiac imaging: A comparative study in PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGYBy: Olianti C., Giardini F., Lazzeri E., Costantini I., Silvestri L., Coppini R., Cerbai E., Pavone F.S., Sacconi L. Year: 2022 (IF.: 3.800 Cit.: 10 DOI: 10.1016/j.pbiomolbio.2021.07.012)
22) Fiber enhancement and 3D orientation analysis in label-free two-photon fluorescence microscopy in SCIENTIFIC REPORTSBy: Sorelli Michele; Costantini Irene; Bocchi Leonardo; Axer Markus; Pavone Francesco Saverio; Mazzamuto Giacomo Year: 2023 (IF.: 3.800 Cit.: 3 DOI: 10.1038/s41598-023-30953-w)
23) Towards a clearer view of sympathetic innervation of cardiac and skeletal muscles in PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGYBy: Di Bona A., Vita V., Costantini I., Zaglia T. Year: 2020 (IF.: 3.667 Cit.: 18 DOI: 10.1016/j.pbiomolbio.2019.07.003)
24) Correlative two-photon and light sheet microscopy in METHODSBy: Silvestri L., Allegra Mascaro A. M., Costantini I., Sacconi L., Pavone F. S. Year: 2014 (IF.: 3.645 Cit.: 26 DOI: 10.1016/j.ymeth.2013.06.013)
25) Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters in NEUROPHOTONICSBy: Yang JR., Chen IA., Chang SB., Tang JB., Lee B., Kiliz K., Sunil S., Wang H., Varadarajan D., Magnain C., Chen SC., Costantini I., Pavone F., Fischl B., Boas DA. Year: 2020 (IF.: 3.593 Cit.: 11 DOI: 10.1117/1.NPh.7.4.045005)
26) Large-scale, cell-resolution volumetric mapping allows layer-specific investigation of human brain cytoarchitecture in BIOMEDICAL OPTICS EXPRESSBy: Costantini I., Mazzamuto G., Roffilli M., Laurino A., Castelli FM., Neri M., Lughi G., Simonetto A., Lazzeri E., Pesce L., Destrieux C., Silvestri L., Conti V., Guerrini R., Pavone FS Year: 2021 (IF.: 3.562 Cit.: 18 DOI: 10.1364/BOE.415555)
27) Comparison of Different Tissue Clearing Methods for Three-Dimensional Reconstruction of Human Brain Cellular Anatomy Using Advanced Imaging Techniques in FRONTIERS IN NEUROANATOMYBy: Scardigli M., Pesce L., Brady N., Mazzamuto G., Gavryusev V., Silvestri L., Hof PR., Destrieux C., Costantini I., Pavone FS. Year: 2021 (IF.: 3.543 Cit.: 10 DOI: 10.3389/fnana.2021.752234)
28) Label-free near-infrared reflectance microscopy as a complimentary tool for two-photon fluorescence brain imaging in BIOMEDICAL OPTICS EXPRESSBy: Allegra Mascaro A.L., Costantini I., Margoni E., Iannello G., Bria A., Sacconi L., Pavone F.S. Year: 2015 (IF.: 3.344 Cit.: 13 DOI: 10.1364/BOE.6.004483)
29) Clearing of fixed tissue: a review from a microscopist´s perspective in JOURNAL OF BIOMEDICAL OPTICSBy: Silvestri L., Costantini I., Sacconi L., Pavone F.S. Year: 2016 (IF.: 2.530 Cit.: 104 DOI: 10.1117/1.JBO.21.8.081205)
30) Mesoscopic Optical Imaging of Whole Mouse Heart in JOVE-JOURNAL OF VISUALIZED EXPERIMENTSBy: Giardini F., Lazzeri E., Olianti C., Beconi G., Costantini I., Silvestri L., Cerbai E., Pavone FS., Sacconi L. Year: 2021 (IF.: 1.424 Cit.: 4 DOI: 10.3791/62795)
31) Comprehensive optical and data management infrastructure for high-throughput light-sheet microscopy of whole mouse brains in NEUROPHOTONICSBy: Muellenbroich M.C., Silvestri L., Onofri L., Costantini I., Van’t Hoff M., Sacconi L., Iannello G., Pavone F.S. Year: 2015 (Cit.: 17 DOI: 10.1117/1.NPh.2.4.041404)
32) Micron-scale Resolution Optical Tomography of Entire Mouse Brains with Confocal Light Sheet Microscopy in JOVE-JOURNAL OF VISUALIZED EXPERIMENTSBy: Silvestri L., Bria A., Costantini I., Sacconi L., Peng H., Iannello G., Pavone F.S. Year: 2013 (Cit.: 17 DOI: 10.3791/50696)
33) High-fidelity imaging in brain-wide structural studies using light-sheet microscopy in ENEUROBy: Müllenbroich M.C., Silvestri L., Di Giovanna A.P., Mazzamuto G., Costantini I., Sacconi L., Pavone F.S. Year: 2018 (Cit.: 13 DOI: 10.1523/ENEURO.0124-18.2018)
34) Deep learning-based localization algorithms on fluorescence human brain 3D reconstruction: a comparative study using stereology as a reference in SCIENTIFIC REPORTSBy: Checcucci C., Wicinski B., Mazzamuto G., Scardigli M., Ramazzotti J., Brady N., Pavone FS., Hof PR., Costantini I., Frasconi P. Year: 2024 (Cit.: 1 DOI: 10.1038/s41598-024-65092-3)
35) Optical Clearing and Labeling for Light-sheet Fluorescence Microscopy in Large-scale Human Brain Imaging in JOVE-JOURNAL OF VISUALIZED EXPERIMENTSBy: Di Meo D., Ramazzotti J., Scardigli M., Cheli F., Pesce L., Brady N., Mazzamuto G., Costantini I., Pavone FS. Year: 2024 ( DOI: 10.3791/65960)
36) Segmentation of supragranular and infragranular layers in ultra-high-resolution 7T ex vivo MRI of the human cerebral cortex in CEREBRAL CORTEXBy: Zeng XR., Puonti O., Sayeed A., Herisse R., Mora J., Evancic K., Varadarajan D., Balbastre Y., Costantini I., Scardigli M., Ramazzotti J., Di Meo D., Mazzamuto G., Pesce L., Brady N., Cheli F., Pavone F.S., Hof P.R., Frost R., Augustinack J., Van der Kouwe A., Iglesias J.E., Fischl B. Year: 2024 ( DOI: 10.1093/cercor/bhae362)
37) Three-dimensional analysis of human brain cytoarchitectonics by means of a SWITCH/TDE-combined clearing method in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Costantini I., Mazzamuto G., Laurino A., Lazzari E., Sacconi L., Neri M., Simonetto A., Ruffilli M., Silvestri L., Pavone FS. Year: 2019 38) 3D human brain digital istopatology in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Costantini I., Mazzamuto G., Silvestri L., Neri M., Roffilli M., Conti V., Guerrini R., Sacconi L., Pavone F.S. Year: 2018 ( DOI: 10.1364/BRAIN.2018.BF4C.1)
39) Automatic Segmentation of Neurons in 3D Samples of Human Brain Cortex in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Mazzamuto G., Costantini I., Neri M., Roffilli M., Silvestri L., Pavone F.S. Year: 2018 40) Software tools for efficient processing of high-resolution 3D images of macroscopic brain samples in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Mazzamuto G., Silvestri L., Costantini I., Orsini F., Roffilli M., Frasconi P., Sacconi L., Pavone F.S. Year: 2018 41) Towards a full volumetric atlas of cell-specific neuronal spatial organization in the entire mouse brain in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Silvestri L., Di Giovanna A.P., Mazzamuto G., Leergard T., Orsini F., Costantini I., Bjaalie J., Frasconi P., Pavone F.S. Year: 2018 42) Whole heart cytoarchitecture at sub-cellular resolution in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Lazzeri E., Costantini I., Cannazzaro S., Ferrantini C., Mazzamuto G., Crocini C., Cerbai E., Poggesi C., Pavone FS., Sacconi L. Year: 2018 43) Correlative polarized light imaging and two-photon fluorescence microscopy for 3D myelinated fibers reconstruction in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Costantini I., Menzel M., Silvestri L., Schubert N., Axer M., Amunts K., Pavone F.S. Year: 2017 44) Fast, image-based autofocus system for high-resolution optical microscopy of whole mouse brains in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Silvestri L., Müllenbroich M.C., Costantini I., Di Giovanna A.P., Sacconi L., Pavone F.S. Year: 2017 ( DOI: 10.1364/BODA.2017.JTu4A.8)
45) Optimal staining and clearing protocol for whole mouse brain vasculature imaging with light-sheet microscopy in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Di Giovanna A.P., Tibo A., Silvestri L., Muellenbroich M.C., Costantini I., Sacconi L., Frasconi P., Pavone F.S. Year: 2017 46) Combination of two-photon fluorescence microscopy and label-free near-infrared reflectance: A new complementary approach for brain imaging in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Costantini I., Mascaro A.L.A., Margoni E., Iannello G., Bria A., Sacconi L., Pavone F.S. Year: 2016 ( DOI: 10.1364/CANCER.2016.JW3A.23)
47) Towards automated neuron tracing via global and local 3D image analysis in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Acciai L., Costantini I., Pavone F.S., Conti V., Guerrini R., Soda P., Iannello G. Year: 2016 48) A multi modal clearing method for brain imaging in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Costantini I., Mascaro A.L.A., Di Giovanna A.P., Silvestri L., Müllenbroich M.C., Sacconi L., Pavone F.S. Year: 2015 ( DOI: 10.1364/BRAIN.2015.BrM3B.2)
49) A new versatile clearing method for brain imaging in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Costantini I., Di Giovanna A.P., Allegra Mascaro A.L., Silvestri L., Müllenbroich M.C., Sacconi L., Pavone F.S. Year: 2015 ( DOI: 10.1117/12.2076908)
50) A versatile new technique to clear mouse and human brain in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Costantini I., Di Giovanna A.P., Mascaro A.L.A., Silvestri L., Müllenbroich M.C., Sacconi L., Pavone F.S. Year: 2015 ( DOI: 10.1117/12.2184289)
51) Brain imaging from the nano- to the macro-scale in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Silvestri L., Allegra Mascaro A.L., Costantini I., Sacconi L., Pavone F.S. Year: 2015 ( DOI: 10.1109/NER.2015.7146760)
52) Brain-wide charting of neuronal activation maps with cellular resolution in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Silvestri L., Rudinskiy N., Paciscopi M., Müllenbroich M.C., Costantini I., Sacconi L., Frasconi P., Hyman B.T., Pavone F.S. Year: 2015 ( DOI: 10.1364/BRAIN.2015.BrM3B.6)
53) Computer-based automatic identification of neurons in gigavoxel-sized 3D human brain images in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Soda P., Acciai L., Cordelli E., Costantini I., Sacconi L., Pavone F.S., Conti V., Guerrini R., Frasconi P., Iannello G. Year: 2015 54) Multiphoton microscopy in brain imaging in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Allegra Mascaro A.L., Silvestri L., Costantini I., Sacconi L., Maco B., Knott G.W., Pavone F.S. Year: 2015 ( DOI: 10.1117/12.2084183)
55) Whole brain optical imaging in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Silvestri L., Allegra Mascaro A.L., Costantini I., Sacconi L., Pavone F.S. Year: 2015 ( DOI: 10.1117/12.2087339)
56) Exploring the brain on multiple scales with correlative two-photon and light sheet microscopy in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Silvestri L., Allegra Mascaro A.L., Costantini I., Sacconi L., Pavone SF. Year: 2014 ( DOI: 10.1117/12.2037867)
57) Neural plasticity explored by correlative two-photon and electron/spim microscopy in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSBy: Mascaro A.L.Allegra, Silvestri L., Costantini I., Sacconi L., Maco B., Knott G.W., Pavone F.S. Year: 2013 ( DOI: 10.1117/12.2032505)
